Services: ObaCell® SVF Fat-on-a-Chip
ObaCell® was created as a tool for disease modeling and drug screening; moreover, it's a versatile plug-and-play system capable of seamless integration with other organ-on-a-chip models, offering boundless potential for transformative research and innovation.
ObaCell® SVF Fat-on-a-Chip is a ready to use functional adipose organoid model cultured in a 96-well plate format. Customize your model by choosing a unique cell donor(s) from our diverse inventory that best represents the prevalent population modeled in your study. Choose up to 4 cell donors per plate. A 3-week lead time is needed to initiate culture in our lab before completing endpoint services.
The Stromal Vascular Fraction (SVF) represents a native multicellular population extracted from adipose tissue including endothelial progenitor cells, mesenchymal stem cells, and immune cells.
Key Features
- Multi-cellular population retained within hydrogel scaffold
- In-vitro self-assembled organoids
- Physiologically and functionally relevant human-derived adipose model
- Matrix protein profile supports cell growth, motility, and vascular response
Applications
- Drug Screening
- Biomedical Device Evaluation
- This model is suitable for studies involving immune cell responses, vascular network formation, adipocyte differrentiation, cytokine release, and image analysis.
Endpoint Services
Metabolic Activity
Cell Viability Staining
Secretome Analysis
Cytokine Profiles
RNA and Protein Expression
Histological Staining and Analysis
Microscopy
Bright-field
Fluorescent
Confocal
High-Throughput
Service Inquiry
Please fill out and submit the form below with details regarding your service request for this model. Our Sales team will return your response asap. If you incur any issues with the form, please email orders@obatalasciences.com
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Relevant Publications
2024
Adipose Tissue in Breast Cancer Microphysioloigical Models to Capture Human Diversity in Preclinical Models. Int. J. Mol. Sci. 2024, 25, 2728.
2021
Adipose-derived cells: building blocks of three-dimensional microphysiological systems. Biomater Transl. 2021 Dec 28;2(4):301-306.
Human Adipose-Derived Stromal/Stem Cell Culture and Analysis Methods for Adipose Tissue Modeling In Vitro: A Systematic Review. Cells. 2021 Jun 3;10(6):1378.
2020
Human Adipose Derived Cells in Two- And Three-Dimensional Cultures: Functional Validation of an In Vitro Fat Construct. Stem Cells Int. 2020 Jun 10
Fat-on-a-Chip Models for Research and Discovery in Obesity and Its Metabolic Co-Morbidities Tissue Eng Part B Rev. 2020 Mar 26.
Adipose Tissue-Derived Stem Cells Retain Their Adipocyte Differentiation Potential in Three-Dimensional Hydrogels and Bioreactors. Biomolecules. 2020 Jul; 10(7): 1070.
Safety of Human Adipose Stromal Vascular Fraction Cells Isolated With a Closed System Device in an Immunocompetent Murine Pressure Ulcer Model. Stem Cells Dev. 2020 Apr 1 (services, cells)
Arguments for a Different Regulatory Categorization and Framework for Stromal Vascular Fraction. Stem Cells and Development, January 6, 2020
2017
Adipose Stromal Vascular Fraction-Mediated Improvements at Late-Stage Disease in a Murine Model of Multiple Sclerosis. Stem Cells vol. 35 pg. 532-544